Kauri Health Clinic · BTS Punnawithi

Syphilis: testing, treatment and what to know

Understand stages, antibody tests, RPR follow-up and treatment.

What is syphilis?

Syphilis is a sexually transmitted infection caused by the bacterium Treponema pallidum. It can begin with a painless sore, progress to a rash, or remain silent for years. Antibiotics can cure the infection, but symptoms disappearing does not mean it has cleared. Blood tests, examination and any previous treatment history help establish the stage and the right treatment plan.

Infection type
Bacterial infection
Relevant sample
Blood testing
Treatment outlook
Curable with appropriate antibiotics

How is syphilis transmitted?

Syphilis spreads through direct contact with an infectious sore during vaginal, anal or oral sex. Sores can be hidden inside the mouth, vagina or rectum. It can also pass from a pregnant person to their baby. Condoms reduce risk but may not cover every affected area. Toilet seats, shared meals and ordinary social contact do not spread syphilis.

What are the symptoms and stages of syphilis?

A first sore commonly appears about 3 weeks after infection, but the range is 10–90 days. It is often painless and can go unnoticed. Secondary syphilis may cause a rash, including on the palms and soles, swollen glands, fever or patchy hair loss. Latent syphilis has no visible symptoms. Years later, untreated infection may damage the heart, brain or other organs; eye, ear and neurological involvement can occur at any stage.

How long does syphilis stay in the body?

Without effective treatment, syphilis can remain in the body for years or decades, even after a sore or rash heals. After successful treatment, treponemal antibody tests often stay positive for life. That is an immune-system record, not proof that treatment failed. RPR levels, symptoms and past results help assess response and possible reinfection. Previous syphilis does not protect you from getting it again.

Which tests diagnose syphilis: antibody, RPR or TPPA?

Diagnosis usually combines a treponemal test, such as syphilis antibody or TPPA, with a nontreponemal test such as RPR. The first detects an immune response to the organism; RPR helps assess activity and follow treatment. TPPA may clarify a result when other tests disagree—it is not automatically needed for everyone. Very early infection can test negative, so a recent exposure or suspicious sore may need repeat testing and examination.

How is syphilis treated?

Penicillin is the standard treatment. The formulation and course depend on the stage, previous treatment and whether the eyes, ears or nervous system are involved. Early disease and late or unknown-duration infection need different plans. Kauri provides medication for syphilis following physician assessment. Tell the doctor about pregnancy or penicillin allergy. New vision changes, hearing loss or neurological symptoms need urgent assessment rather than a routine screening appointment.

What happens after syphilis treatment?

Follow-up blood tests track the RPR titre over time; bring previous reports so the doctor can compare like with like. Partners may need testing and treatment even if they feel well. Avoid sexual contact until treatment is completed, sores have healed and your clinician confirms it is appropriate to resume. A short-lived fever or aches can occur after treatment begins; seek advice if you feel unwell. Severe allergic symptoms require emergency care.

Patient questions

Syphilis: common questions

Can I have syphilis without symptoms?

Yes. A sore may be hidden or painless, and latent syphilis has no symptoms. Testing is useful after a relevant exposure, a partner diagnosis or when recommended during routine sexual-health care.

Can a urine STI panel replace syphilis blood tests?

No. The 18-target urine panel lists Treponema pallidum, but a urine result does not replace standard syphilis blood testing, staging or RPR follow-up. For a syphilis concern, discuss the blood panel or appropriate individual blood tests.

Relevant testing options at Kauri

Choose a focused test or a broader panel according to your concern. The options below link to the complete STI menu, where you can compare coverage and preparation.

Applicable individual blood tests

View individual blood tests

Syphilis antibody and RPR are included in the four-infection blood panel. TPPA is a separate option when clinically useful, not an automatic extra test. The 18-target urine panel's Treponema pallidum target does not replace syphilis blood testing or RPR follow-up.

Panel turnaround starts after sample collection; it is not the time from exposure until infection becomes detectable. Individual-test timing and any additional clinical assessment are confirmed separately.

STI clinical references

Updated 17 October 2026. Educational information based on the clinical sources below; Kauri supplied the listed service availability and prices. Your assessment determines the tests and treatment appropriate for you.

  1. CDC: About Syphilis
  2. CDC: Syphilis Treatment Guidelines
  3. CDC: Syphilis Laboratory Recommendations

Kauri Health Clinic · BTS Punnawithi

Plan a confidential visit at BTS Punnawithi

Kauri Health Clinic is at BTS Punnawithi, 3063 Sukhumvit Rd, Bang Chak, Phra Khanong, Bangkok 10260. Open Tuesday–Saturday, 9:00–18:00; closed Sunday and Monday. Tell us your concern, when any exposure happened and whether you have symptoms. Bring previous results and a list of medicines; the team will explain preparation and next steps privately.

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